Chondroid syringoma associated with hidrocystoma‐like changes. Possible differentiation into eccrine gland. A histologic, immunohistochemical and electron microscopic study

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Abstract
A case of chondroid syringoma associated with hidrocystoma‐like changes was investigated by histology, immunohistochemistry and electron microscopy. Chondroid syringoma was histologically compatible with apocrine mixed tumor, and hidrocystoma‐like changes did not fulfill diagnostic criteria of either eccrine hidrocystoma or apocrine hidrocystoma. However, epithelial cellular elements composing both chondroid syringoma and hidrocystoma‐like changes suggested, immunohistochemically and electron microscopically, differentiation into eccrine gland. The lesions of both had an apparent transition of ductal structures of chondroid syringoma into hidrocystoma‐like changes. Therefore, chondroid syringoma and hidrocystoma‐like changes in this case may be organized as a peculiar type of cutaneous appendage tumor differentiating toward eccrine gland.

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