Structure and diversity of insect nicotinic acetylcholine receptors
- 5 September 2001
- journal article
- review article
- Published by Wiley in Pest Management Science
- Vol. 57 (10) , 914-922
- https://doi.org/10.1002/ps.349
Abstract
The nicotinic acetylcholine receptor (nAChR) is an agonist‐regulated ion‐channel complex responsible for rapid neurotransmission. The vertebrate nAChR, assembled from five homologous subunits, penetrates the synaptic membrane. Different subunit combinations lead to receptor subtypes with distinctive pharmacological profiles. In comparison with mammalian nAChRs, the insect receptor is poorly understood relative to functional architecture and diversity. Several genes for Drosophila, Locusta and Myzus encoding insect nAChR subunits have been identified, although the functional assembly and presence of different subtypes of these receptors are not defined. The insect nAChR is the primary target site for the neonicotinoid insecticides, thereby providing an incentive to explore its functional architecture with neonicotinoid radioligands, photoaffinity probes and affinity chromatography matrices. This review considers the current understanding of the structure and diversity of insect nAChRs based mainly on recent studies in molecular biology and protein biochemistry.© 2001 Society of Chemical IndustryKeywords
This publication has 60 references indexed in Scilit:
- Neuronal nicotinic acetylcholine receptors of Drosophila melanogaster: the α‐subunit Dα3 and the β‐type subunit ARD co‐assemble within the same receptor complexFEBS Letters, 2000
- Insect Nicotinic Acetylcholine Receptor: Conserved Neonicotinoid Specificity of [3H]Imidacloprid Binding SiteJournal of Neurochemistry, 2000
- Minor structural changes in nicotinoid insecticides confer differential subtype selectivity for mammalian nicotinic acetylcholine receptorsBritish Journal of Pharmacology, 1999
- Novel Neonicotinoid‐Agarose Affinity Column for Drosophila and Musca Nicotinic Acetylcholine ReceptorsJournal of Neurochemistry, 1996
- A nicotinic acetylcholine receptor subunit from insect brain forms a non-desensitising homo-oligomeric nicotinic acetylcholine receptor when expressed in Xenopus oocytesNeuroscience Letters, 1995
- [3H]imidacloprid: Synthesis of a candidate radioligand for the nicotinic acetylcholine receptorJournal of Labelled Compounds and Radiopharmaceuticals, 1992
- Neuronal Nicotinic Acetylcholine Receptors in Drosophila: Antibodies Against an α‐Like and a Non‐α‐Subunit Recognize the Same High‐Affinity α‐Bungarotoxin Binding ComplexJournal of Neurochemistry, 1991
- Structure and developmental expression of the Dα2 gene encoding a novel nicotinic acetylcholine receptor protein of Drosophila melanogasterFEBS Letters, 1990
- Comparison of the toxin binding sites of the nicotinic acetylcholine receptor from Drosophila to humanBiochemistry, 1990
- Amino acid sequence of α-bungarotoxin from the venom of bungarus multicinctusBiochemical and Biophysical Research Communications, 1971