Effects of Several Analgesics on the Number of Vocalization Discharges of the Rabbit

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Abstract
Vocalization (squeal, cry) has been used as a signal of pain in animals by a number of investigators. Nevertheless, previous workers have raised the question of whether or not vocalization in rabbits can be regarded as a reliable index of pain for evaluating analgesic actions of drugs. Morphine, pentazocine, sodium salicylate, aminopyrine, levallorphan, acetylsalicylic acid and mefanamic acid were studied. The number of vocalization discharges was decreased only by morphine and pentazocine which have been classified as centrally-acting analgesics, but not by the remaining analgesics which have been pointed out to be peripherally-acting analgesics.