INVITRO ANTITUBERCULOSIS ACTIVITY OF A NEW ANTIBACTERIAL SUBSTANCE OFLOXACIN (DL8280)

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Abstract
A new antituberculosis agent, ofloxacin (DL8280), inhibited the growth of Mycobacterium tuberculosis at concentrations of 0.63-1.25 .mu.g/ml. There were no cross-resistance relationships between this agent and other antituberculosis agents. The agent delayed the growth rate of M. tuberculosis (strain H37Rv) at concentrations of 0.2-0.5 .mu.g/ml. It showed considerable bactericidal activity at concentrations a little higher than the growth-inhibitory concentration. The combined effect with other antituberculosis agents seemed to be additive. The pattern of resistance that developed with this agent was the obligatory 2-step pattern, and there were 2 resistant phenotypes.

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