SEGREGATION STUDY OF HLA-HAPLOTYPES IN FAMILIES WITH A CHILD SUFFERING FROM SPINA-BIFIDA
- 1 January 1979
- journal article
- research article
- Vol. 27 (3) , 205-219
Abstract
The search for HLA association in spina bifida is particularly interesting since this condition can be associated with the effect of the T locus in mice. Gene and haplotype frequencies in 32 unrelated patients suffering from spina bifida were studied. Patients and families were examined clinically and radiologically. A high frequency of spina bifida occulta and other vertebral abnormalities was found, suggesting genetic determinism. No evidence of linkage with HLA genes or haplotypes was found.This publication has 3 references indexed in Scilit:
- Spina bifida cystica. Incidence of spina bifida occulta in parents and in controls.Archives of Disease in Childhood, 1967
- FREQUENCY OF SPINA BIFIDA OCCULTA AND RIB ANOMALIES IN PARENTS OF CHILDREN WITH SPINA BIFIDA APERTA AND MENINGOCOELE1962
- ON ESTIMATING THE RELATION BETWEEN BLOOD GROUP AND DISEASEAnnals of Human Genetics, 1955