Effect of Substance P and Sar9Met(O2)11-Substance P on Cutaneous Capillary Permeability in Guinea Pig Skin
- 1 January 1992
- journal article
- research article
- Published by S. Karger AG in Skin Pharmacology and Physiology
- Vol. 5 (3) , 171-176
- https://doi.org/10.1159/000211034
Abstract
The purpose of this study was to assess the effect of several drugs on the increase in cutaneous capillary permeability induced by intradermal injection of substance P (SP) and Sar9Met(O2)11-SP in guinea pig skin. On the one hand, the increase in cutaneous capillary permeability was partly reduced by spantide, promethazine, atropine or SR 40037, an inhibitor of the angiotensin-converting enzyme. On the other hand, norepinephrine and B3824, a B2-antagonist of bradykinin, showed an enhancing effect. Our results suggest that the effect of SP and Sar9Met(O2)11-SP in guinea pigs is partly mediated by histamine and acetylcholine, and that there is a relationship between tachykinins and bradykinin.Keywords
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