Multivalent RGD synthetic peptides as potent αVβ3integrin ligands
- 3 April 2006
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Organic & Biomolecular Chemistry
- Vol. 4 (10) , 1958-1965
- https://doi.org/10.1039/b517706e
Abstract
We study herein the multivalency effect of a cluster of αVβ3-ligands held on a cyclodecapeptide template. An array of RAFT(c[-RGDfK-])n derivatives containing from one to sixteen clustered RGD motifs were synthesized and comparatively assayed in vitro on αVβ3-expressing cells. Efficient inhibition of the αVβ3-specific 23C6 monoclonal antibody fixation was observed with ligands displaying three and four copies of the cyclo[-RGDfK-] peptide.Keywords
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