EFFECT ON THE THYROID GLAND OF EXPERIMENTAL ALTERATION OF THE LEVEL OF CIRCULATING THYROXINE IN MICE WITH HETEROTOPIC PITUITARIES1

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Abstract
Thyroid I131 uptake and thyroid/serum (T/S) iodide ratio were studied in hypophysectomized mice bearing intraocular pituitary implants. I131 uptake and T/S ratio were higher in implanted-hypophysectomized mice than in hypophysectomized controls, even though the thyroid weights were the same. Total I131 uptake and T/S ratio in implanted-hypophysectomized mice were equal to those in normals whereas the thyroid weight was 2/3 of normal. Feeding propylthiouracil resulted in a marked increase in the I131 uptake and the T/S ratio in implanted-hypophysectomized mice with a relatively small, but statistically significant, thyroid weight increase. I131 uptake/mg of thyroid gland and T/S ratio were 2-3 times as large in implanted mice fed propylthiouracil as in similarly fed normal controls. Thyroxine injections produced a depression of I131 uptake by the thyroid in both implanted-hypophysectomized and normal animals but had no significant effect on thyroid weight. Thyroid glands of hypophysectomized control mice were unaffected by propylthiouracil-feeding and by thyroxine.

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