Dysgerminoma of the Ovary with Widespread Metastases

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Abstract
In 1931, Meyer first applied the term “dysgerminoma” to the ovarian counterpart of the testicular seminoma. Although there are approximately 200 cases reported in the literature up to 1939 (1), the dysgerminoma is a relatively uncommon ovarian neoplasm, its frequency being variously reported as 3 to 10 per cent of primary malignant tumors of the ovary (1, 5, 6, 7). It appears typically at an early age, becoming manifest most often in the second to fourth decades, and is characterized by a progressively enlarging pelvic mass which may reach large proportions. When this finding is associated with pseudohermaphroditism or other genital maldevelopment, the diagnosis should be strongly suspected. Novak (5), however, has pointed out that more than one-half of his patients had normal genital development. Various degrees of ascites may be present in about 10 per cent of patients (7). The tumor is believed to be hormonally indifferent (3, 5), in conformity with Meyer's concept of its origin from “an undifferentiat...

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