Complement component profiles in urticaria, dermatitis herpetiformis, and alopecia areata

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Abstract
Insignificant variation was noted in the mean levels of the complement [C] components C1q [q fragment of the 1st C component], C4, C2, C3, C5 and C3PA [C3 proactivator] between various groups of sera from patients with urticaria, angio-edema, dermatitis herpetiformis, alopecia areata or hay fever. No deficiencies were found. Elevated C9 levels in chronic urticaria and angio-edema reflected its nature as an acute phase protein. The assessment of C components in single or sequential serum samples revealed only marginal variations. Similar results were recorded for plasminogen and the immunoglobulins G, A and M. There is apparently a primary involvement of the kallikrein-kinin system in urticaria.

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