Potential long-acting anticonvulsants. 1. Synthesis and activity of succinimides containing an alkylating group at the 2 position

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Abstract
The synthesis of succinimide derivatives in which alkylating groups were attached to the 2 position of the ring or to the para position of the 2-phenyl substituent was described. The alkylating groups used were .alpha.-haloacetyl, .alpha.-haloacetamido, maleimido and maleamyl. These compounds were prepared as potential long-acting anticonvulsants [and tested in mice]. Several of these derivatives exhibited activity against metrazole-induced seizures comparable to phensuximide. A maleimide and a bromoacetamido derivative exhibited a duration of action of at least 3.5 h.