Mutation of traP in Staphylococcus aureus Has No Impact on Expression of agr or Biofilm Formation

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Abstract
To investigate the regulatory role of traP ( t arget of R NAIII- a ctivating p eptide) in Staphylococcus aureus , we generated traP mutations in the clinical isolates UAMS-1 and USA300. In neither case did mutation of traP affect expression of the accessory gene regulator ( agr ) or the ability to form a biofilm. We were also unable to confirm that mutation of traP in the prototype 8325-4 laboratory strain RN6390 results in reduced expression of agr , reduced hemolytic activity, or an altered capacity to form a biofilm.

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