Human Influenza A Virus–Specific CD8+ T-Cell Response Is Long-lived
Open Access
- 12 January 2015
- journal article
- research article
- Published by Oxford University Press (OUP) in The Journal of Infectious Diseases
- Vol. 212 (1) , 81-85
- https://doi.org/10.1093/infdis/jiv018
Abstract
Animal and human studies have demonstrated the importance of influenza A virus (IAV)-specific CD8+ cytotoxic T lymphocytes (CTLs) in heterosubtypic cross-protective immunity. Using peripheral blood mononuclear cells obtained intermittently from healthy HLA-typed blood donors between 1999 and 2012, we were able to demonstrate that IAV-specific CTLs are long-lived. Intercurrent IAV infections transiently increase the frequency of functionally distinct subsets of IAV-specific CTLs, in particular effector and effector memory T cells.Keywords
This publication has 16 references indexed in Scilit:
- Cellular immune correlates of protection against symptomatic pandemic influenzaNature Medicine, 2013
- Evasion of Influenza A Viruses from Innate and Adaptive Immune ResponsesViruses, 2012
- Annual Vaccination against Influenza Virus Hampers Development of Virus-Specific CD8+T Cell Immunity in ChildrenJournal of Virology, 2011
- Characterization of the Human CD8+T Cell Response following Infection with 2009 Pandemic Influenza H1N1 VirusJournal of Virology, 2011
- Prevalence of Antibodies against Seasonal Influenza A and B Viruses in Children in NetherlandsClinical and Vaccine Immunology, 2011
- Insights into human CD8+ T‐cell memory using the yellow fever and smallpox vaccinesImmunology & Cell Biology, 2011
- Early establishment of diverse T cell receptor profiles for influenza-specific CD8+CD62Lhimemory T cellsProceedings of the National Academy of Sciences, 2006
- T cells and viral persistence: lessons from diverse infectionsNature Immunology, 2005
- Influenza Virus: a Master of MetamorphosisJournal of Infection, 2000
- Two subsets of memory T lymphocytes with distinct homing potentials and effector functionsNature, 1999