Response of Rheumatoid Arthritis with Leukopenia to Gold Salts

Abstract
The place of gold salts in the treatment of rheumatoid arthritis, after many years of controversy, was firmly established in a multicenter controlled trial in 1960.1 Severe cases of rheumatoid arthritis are frequently complicated by granulocytopenia. The safety and effectiveness of gold salts in these cases has not been well established. Leukopenia is a known complication of therapy, and is listed as a relative contraindication.Many patients with rheumatoid arthritis and leukopenia also have splenomegaly, and to these cases the term Felty's syndrome2 has been applied. Leukopenia was thought to be the result of entrapment and destruction of the white . . .

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