A comparative serological and molecular study of linear IgA disease and dermatitis herpetiformis

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Abstract
The class I and class II HLA serologically defined antigens and DQ.alpha. and DX.alpha. restriction fragments length polymorphism (RFLP) in 23 patients with linear IgA disease (LAD) were determined and their frequencies compared with those in a group of patients with dermatitis herpetiformis (DH) and healthy controls. In LAD there was a significant increase in HLA-B8 and DR3 and a larger increase in the DQWI-DR2/DRw6 related DQ.alpha. 6.2 kb and 6.8 kb RFLP. In DH there was a significantly increased frequency of HLA-AI, B8, DR3, and DQW2 with a concomitant increase in the DR3-DQW2 related DQ.alpha. 4.6 kg RFLP. The difference in DR3 frequencies and the increased frequency of DQWI rather than DQW2 in LAD indicates that different susceptibility genes operate in the two diseases.