Mammary Tumour Incidence in Relation to the Pattern of Oestrous Cycles in Mice

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Abstract
The patterns of oestrous cycles were examined in new strains of mice exhibiting a high (SHN) and a low (SLN) mammary tumour incidence. These mice originated from the same stock of Swiss albino mice. At the age of 3–4 months, SHN mice showed much longer cycles with continual dioestrous periods than SLN mice. The average lengths of cycles and dioestrous periods were, respectively, 8.3 ± 0.3 and 6.0 ± 0.4 days in SHN mice and 4.6 ± 0.1 and 2.5 ± 0.1 days in SLN mice. Furthermore, the distinct alteration in the patterns of cycles from SHN to SLN type was associated with complete reduction in mammary tumour incidence in highly inbred C3H/He female mice maintained by brother X sister mating with no selection for mammary tumourigenesis. The relation between the pattern of oestrous cycles and mammary tumourigenesis is discussed from the viewpoint of the endogenous hormonal milieu and the responsiveness of target organs.