MAMMARY GLAND DEVELOPMENT WITH MAMMOGEN I IN THE CASTRATE AND THE HYPOPHYSECTOMIZED RAT1

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Abstract
A lipid mammogen I extract of pregnant cattle AP gave only negative results in 6 injns. into castrate [male] rats at total dosages of 0.02 to 1.6 mammogenic mouse u. Positive results were obtained when treatment was continued for 28-30 days at dosages of 0.04 to 3.2 m.u. per 6 days. A lipid extract of cattle AP caused duct growth at dosages of 12-48 m.u. per 6 days. A 2d extract of pregnant cattle AP gave strong results at 300 m.u. per 6 days. Sixteen 25 to 44 day old [male] and [female] rats were hypophysectomized and treated with a lipid extract of pregnant cattle AP for 7 to 10 days. 15 showed evidence of mammary duct growth on autopsy. Dosages ranged from 4-16 m.u. per day. 10 hypophysectomized [female] rats served as controls. The wts. of the thyroids, adrenals, ovaries and uteri of the treated hypophysectomized 2 rats were compared with similar untreated rats. Only in the case of the adrenals was the difference significant. Adrenals from treated rats were smaller than those from controls. Avg. wts. of all these organs in both groups were much under similar wts. from normal unoperated control rats. These data show that lipid AP extracts will grow the mammary duct, systems of castrate [male] and hypophysectomized [male] and [female] rats.