TRIAMTERENE UROLITHIASIS - SOLUBILITY, PK, EFFECT ON CRYSTAL-FORMATION, AND MATRIX BINDING OF TRIAMTERENE AND ITS METABOLITES

  • 1 January 1982
    • journal article
    • research article
    • Vol. 99  (2) , 254-262
Abstract
The commonly used diuretic Tri [triamterene] and its metabolites are major components of some kidney stones. Basic physical chemical studies determined the mechanism of Tri incorporation into kidney stones. The solubility and pK of Tri and its major metabolites, Tri-OH and the Tri-SO4, were determined at 37.degree. C in 0.15 M NaCl. The effect of Tri and its metabolites on crystal formation was measured in the calcium oxalate monohydrate, hydroxylapatite and uric acid crystal systems. Tri and its metabolites do not promote crystal nucleation, growth or aggregation in any of these crystal systems and are not incorporated as these crystals form. Binding of Tri and its metabolites to the protein matrix isolated from kidney stones was demonstrated. Evidently Tri and its metabolites do not promote the formation of kidney stones but rather become incorporated into existing stones or stone nidi by binding to the protein matrix found in all kidney stones.

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