Cardiotonic ‘C’ Ring Modified Isomazole Analogues
- 1 January 1990
- journal article
- research article
- Published by Wiley in Archiv der Pharmazie
- Vol. 323 (8) , 507-512
- https://doi.org/10.1002/ardp.19903230812
Abstract
Isomazole analogues which have achiral electron withdrawing substituents at the 4′‐position and analogues with heterocyclic ‘C’ rings have been synthesized and evaluated as inotropic agents. It was found that pyridyl could replace phenyl in the ‘C’ ring without loss of activity. The 4′‐methylsulphonyl, ‐cyano, ‐carboxamido, and acetyl analogues had similar inotropic potencies to Isomazole whilst displaying superior cardiovascular profiles in in vivo studies.This publication has 12 references indexed in Scilit:
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