Isolation of Infectious Xenotropic Mouse Type C Virus by Transfection of a Heterologous Cell with DNA from a Transformed Mouse Cell

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Abstract
An endogenous xenotropic type C virus has been isolated from a Kirsten sarcoma virus-transformed BALB/c mouse cell line by transfection of a mink fibroblast cell with the DNA from the transformed cells. The results indicate that transfection may be used as a technique to isolate this endogenous type C virus without the need to chemically induce the cell line containing the provirus prior to attempting to isolate the virus.