Utilization of transferrin-bound iron by Haemophilus species of human and porcine origins

1 November 1989

journal article
Published by Oxford University Press (OUP) in FEMS Microbiology Letters

Vol. 65 (1-2) , 123-127
https://doi.org/10.1016/0378-1097(89)90378-9

Abstract

Haemophilus influenzae and H. Haemolyticus acquired iron bound to human transferrin but not to human lactoferrin, ovo- or porcine transferrins. Conversely the swine pathogens H. pleuropneumoniae and H. parasuis used iron bound only to porcine transferrin. Growth under conditions of iron deprivatio induced the production of siderophores and iron-repressible outer membrane proteins in H. parainfleunzae, H. paraphrophilus and H. parasuis but not in H. influenzae, H. haemolyticus or H. pleurophneumoniae. The latter 3 Haemophilus species appear to sequester transferrin bound iron via a siderophore-independent mechanism. However, the ability to produce iron chelating compounds did not enable H. parainfluenzae or H. paraphrophilus to utilize transferin bound iron.

Keywords

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