Studies on the Pharmacologic Action and the Pathology of Alphanaphthylthiourea (ANTU)

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Abstract
The acute and chronic toxicity of a-naphthylthiourea (ANTU) was studied in albino rats, rabbits, cats, and dogs, with the following results. The acute toxicity of ANTU varies in different animal spp., rats and dogs being the most susceptible and rabbits the least. Pleural, and to a lesser extent pericardial, effusions are characteristically present in all spp. if death is not delayed much beyond 24 hrs. The effusions have a protein content usually over 1/2 that of the plasma. Tolerance to the acute toxicity of ANTU can be induced in rats by administering progressively increasing doses at 3-4-day intervals. No effusions have been found in tolerant rats dying from large doses. Chronic toxicity expts. in rabbits and cats indicate a cumulative action. In chronically poisoned cats effusions are absent, but instead bili-rubinemia is regularly produced and this seems to be the result of altered capillary permeability with leakage of bile from the bile channels into the venous sinusoids.

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