Increased tolerance and conversion of inhibitors in lignocellulosic hydrolysates by Saccharomyces cerevisiae
Top Cited Papers
- 5 April 2007
- journal article
- review article
- Published by Wiley in Journal of Chemical Technology & Biotechnology
- Vol. 82 (4) , 340-349
- https://doi.org/10.1002/jctb.1676
Abstract
During hydrolysis of lignocellulosic biomass, monomeric sugars and a broad range of inhibitory compounds are formed and released. These inhibitors, which can be organized around three main groups, furans, weak acids and phenolics, reduce ethanol yield and productivity by affecting the microorganism performance during the fermentation step. Among the microorganisms that have been evaluated for lignocellulosic hydrolysate ethanol fermentation, the yeast Saccharomyces cerevisiae appears to be the least sensitive. In order to overcome the effect of inhibitors, strategies that include improvement of natural tolerance of microorganism and use of fermentation control strategies have been developed. An overview of the origin, effects and mechanisms of action of known inhibitors on S. cerevisiae is given. Fermentation control strategies as well as metabolic, genetic and evolutionary engineering strategies to obtain S. cerevisiae strains with improved tolerance are discussed. Copyright © 2007 Society of Chemical IndustryKeywords
This publication has 67 references indexed in Scilit:
- Continuous Fermentation of Undetoxified Dilute Acid Lignocellulose Hydrolysate by Saccharomycescerevisiae ATCC 96581 Using Cell RecirculationBiotechnology Progress, 2008
- Tolerance and adaptation of ethanologenic yeasts to lignocellulosic inhibitory compoundsBiotechnology & Bioengineering, 2006
- Cofactor Dependence in Furan Reduction by Saccharomyces cerevisiae in Fermentation of Acid-Hydrolyzed LignocelluloseApplied and Environmental Microbiology, 2005
- The fermentation performance of nine strains of Saccharomyces cerevisiae in batch and fed-batch cultures in dilute-acid wood hydrolysateJournal of Bioscience and Bioengineering, 2004
- Adaptive response of yeasts to furfural and 5-hydroxymethylfurfural and new chemical evidence for HMF conversion to 2,5-bis-hydroxymethylfuranJournal of Industrial Microbiology & Biotechnology, 2004
- On-line estimation of sugar concentration for control of fed-batch fermentation of lignocellulosic hydrolyzates by Saccharomyces cerevisiaeBioprocess and Biosystems Engineering, 2002
- Fermentative performance of bacteria and yeasts in lignocellulose hydrolysatesProcess Biochemistry, 1993
- Another explanation for the toxicity of fermentation acids at low pH: anion accumulation versus uncouplingJournal of Applied Bacteriology, 1992
- Genetic and Biochemical Analysis of the Ability of Saccharomyces cerevisiae to Decarboxylate Cinnamic AcidsMicrobiology, 1982
- Kinetics of alcohol production by zymomonas mobilis at high sugar concentrationsBiotechnology Letters, 1979