Synthesis and structure-activity relationship of spiro(isochroman-piperidine) analogs for inhibition of histamine release. III.

1 January 1983

journal article
research article
Published by Pharmaceutical Society of Japan in CHEMICAL & PHARMACEUTICAL BULLETIN

Vol. 31 (2) , 521-526
https://doi.org/10.1248/cpb.31.521

Abstract

Several 1-alkyl-4-piperidylidene analogs were synthesized and tested for inhibitory activity on the compound 48/80[p-methoxyphenethyl methylamine-formaldehyde product]-induced release of histamine from [rat] mast cells. 4-(4-Isochromanylidene) and 4-(diphenylmethylene) derivatives of 1-benzylpiperidine were much more active than the Pb compounds, 1-benzylspiro[isochroman-piperidines].

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