Is Colchicine Effective Therapy for Cirrhosis?

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Abstract
Cirrhosis of the liver is a leading cause of death in the United States and a major worldwide health problem.1 The World Health Organization has estimated that the annual death rate from cirrhosis in some nations is as high as 40 persons per 100,000 population.2 Most cases result from chronic viral infection or the excessive use of alcohol, although toxins, drug reactions, immunologic diseases, and certain rare genetic disorders all contribute. Once the complications of cirrhosis develop (ascites, progressive jaundice, encephalopathy, and hemorrhage from esophageal varices), overall survival rates decline rapidly and are usually below 20 percent within five years. . . .