Effects of angiotensin II on the zona glomerulosa of sodium-loaded dexamethasone treated rats administered or not with maintenance doses of ACTH: stereology and plasma hormone concentrations

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Abstract
The trophic effects of angiotensin II on the rat zona glomerulosa were investigated by stereological and radioimmunological methods. Angiotensin II was not able to reverse the Na-loading, and dexamethasone-induced inhibition of the growth and steroidogenic capacity of the zona glomerulosa. However, if the Na-loaded dexamethasone-treated rats were given maintenance doses of ACTH, angiotensin II exerted a strong adrenoglomerulotrophic effect. The hypothesis is advanced that the co-operation of ACTH and angiotensin II is required in the maintenance of the morphologic and enzymatic integrity of the rat zona glomerulosa.