Transcription factors: their potential as targets for an individualized therapeutic approach to cancer
- 10 October 2008
- journal article
- review article
- Published by Springer Nature in Cancer Gene Therapy
- Vol. 16 (2) , 103-112
- https://doi.org/10.1038/cgt.2008.73
Abstract
Pro-cancer signals are controlled by the expression and transcription of oncogenes. Transcription of DNA is dependent on the spatially and temporally coordinated interaction between transcriptional machinery (RNA polymerase II, transcription factors (TFs)) and transcriptional regulatory components (promoter elements, enhancers, silencers and locus control regions). Unique TFs have been identified in association with cancer. This review summarizes key oncogene-related TFs and organizes their pro-cancer activity according to the six hallmark functions (self sufficiency in growth signals, insensitivity to growth-inhibitory signals, evasion of programmed cell death, limitless replicative potential, sustained angiogenesis and metastatic spread) proposed as constituting the infrastructure of the malignant process.Keywords
This publication has 80 references indexed in Scilit:
- A positive role for PEA3 in HER2-mediated breast tumour progressionBritish Journal of Cancer, 2006
- Beyond microarrays: Finding key transcription factors controlling signal transduction pathwaysBMC Bioinformatics, 2006
- The General Transcription Machinery and General CofactorsCritical Reviews in Biochemistry and Molecular Biology, 2006
- NF-κB in cancer: from innocent bystander to major culpritNature Reviews Cancer, 2002
- Constitutive Stat3 activity up-regulates VEGF expression and tumor angiogenesisOncogene, 2002
- The Brn-3b POU family transcription factor regulates the cellular growth, proliferation, and anchorage dependence of MCF7 human breast cancer cellsOncogene, 2001
- AP-1 in cell proliferation and survivalOncogene, 2001
- The Hallmarks of CancerCell, 2000
- The Brn-3b POU family transcription factor represses expression of the BRCA-1 anti-oncogene in breast cancer cellsOncogene, 1999
- The level of a transcription factor Sp1 is correlated with the expression of EGF receptor in human gastric carcinomasBiochemical and Biophysical Research Communications, 1992