ASSOCIATION OF GA-67 AND LACTOFERRIN
- 1 January 1977
- journal article
- research article
- Vol. 18 (7) , 713-717
Abstract
Activity was seen in the breasts of a patient with galactorrhea 72 h after i.v. injection of 67Ga citrate. Differential protein separation of breast secretion, extracted from the breast, revealed that the 67Ga was contained primarily in the lactoferrin-rich protein fraction. Additional studies on partially purified lactoferrin revealed that lactoferrin binds 67Ga more avidly than does transferrin. Since lactoferrin is present in high concentration not only in human colostrum and milk, but also in neutrophilic leukocytes, bone marrow, spleen, colon, tears and in genital, salivary and nasopharyngeal secretions, binding of 67Ga to lactoferrin may explain the localization of 67Ga in certain normal tissues and inflammatory lesions.This publication has 4 references indexed in Scilit:
- UPTAKE OF GA-67 IN LACTATING BREAST AND ITS PERSISTENCE IN MILK - CASE-REPORT1976
- An iron-binding protein common to many external secretionsClinica Chimica Acta; International Journal of Clinical Chemistry, 1966
- The Isolation of a Red Protein from Milk2Journal of the American Chemical Society, 1960
- Turbidimetric Determination of Proteins with Sulfosalicylic and Trichloracetic AcidsExperimental Biology and Medicine, 1956