Thermotolerance effects on thermoradiosensitization in human glioma cells

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Abstract
Human glioma cells were tested to evaluate thermotolerance (TT) development and its effect on radiosensitization. The data show that long duration mild hyperthermia (LDMH) at 40, 41 and 42d`C when given before acute irradiation resulted in increased radiosensitization with heating time. Furthermore, radiosensitization was not reduced by TT. When LDMH was given before 45d`C hyperthermia there was evidence of TT development which reduced radiosensitization compared to heating at 45d`C alone. For 40 and 41d`C heating the effect was maximum for the 8 h heating time while for 42d`C it was generally maximum for the 4 h heating time. At longer heating times of 24 to 48 h the effect of TT declined. Thus while LDMH itself does not display TT for radiosensitization it can in fact produce a TT effect on radiosensitization when used in a stepup-heating protocol with 45d`C.