Mixed venous blood temperature response to exercise in heart failure patients treated with short-term vasodilators

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Abstract
Summary. Deep‐body or core temperature decreases during exercise in patients with heart failure, primarily due to the circulatory inadequacies associated with the pathophysiology of this condition. Vasodilators are commonly used to treat patients suffering from heart failure because these drugs improve total cardiac output and blood‐flow to the regional circulations. In heart failure patients, the core temperature response to exercise should also be affected if the circulation is improved by vasodilators. Patients with severe heart failure were studied at rest and during upright bicycle exercise before, and after, short‐term treatment with vasodilators (2‐minoxidil, 3‐hydralazine, 5‐captopril). Their heart rate increased significantly (P(P decreased at rest and after the administration of vasodilators (mean arterial pressure 88±7 mmHg before; 77±8 mmHg after; pulmonary capillary wedge pressure 25±8 mmHg before, 19±9 mmHg after). During exercise, the increases in mean arterial and pulmonary capillary wedge pressures were not significantly different from the before vasodilator values (mean arterial pressure 92±14 mmHg before, 87±14 mmHg after; pulmonary capillary wedge pressure 31±11 mmHg before, 29± 11 mmHg after). Vasodilators increased cardiac output significantly (PPoC to 36–65±0–65oC, before treatment with vasodilators. After administration of vasodilators, resting core temperature was not significantly different (36–95±0–54oC) and still decreased significantly (P during exercise to 36–73±0–53oC. This decrease was significantly (P different from the core temperature response before the administration of vasodilators. We conclude that heart failure patients, treated with short‐term vasodilators, have an

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