Tissue and Blood Cell Concentration of Methylguanidine in Rats and Patients with Chronic Renal Failure
- 1 January 1981
- journal article
- research article
- Published by S. Karger AG in Nephron
- Vol. 27 (1) , 35-39
- https://doi.org/10.1159/000182017
Abstract
Methylguanidine concentration in blood cell of nondialyzed patients with chronic renal failure was quantitatively determined by a new method. Tissue methylguanidine concentrations were determined in the liver, blood cell, kidney, colon, muscle and brain of uremic rat experimentally produced by Platt''s method. Methylguanidine concentrations in blood cell and tissues except the brain of the uremic rats and in blood cell of the uremic patients were 5-7 times higher than those in their serums. An increased methylguanidine concentration in the liver of the uremic rat receiving 40% protein diet was observed. Methylguanidine acts as one of the important uremic toxins in the intracellular space except for the brain, and the liver specifically affects the formation of methylguanidine.This publication has 1 reference indexed in Scilit: