Immunologic features of a carcinogen‐induced murine bladder cancer: In vivo and in vitro studies

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Abstract
Certain in vivo and in vitro immunologic features of carcinogen‐induced murine bladder cancer have been studied. The consistency of tumor induction, its natural history, and immunogenicity both in vivo and in vitro render this syngeneic murine bladder tumor a suitable model for immunologic studies. Pre‐immunization of strain C3H/Hen mice with mid‐gestational fetal cells did not protect the animals from tumor challenge. Sera of mice immunized with mid‐gestational fetal cells were not cytotoxic to cultured tumor cells in a microcytotoxicity assay indicative of dissimilarity between the tumor associated antigen and the syngeneic mid‐gestational fetal antigen.

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