Collagen for female genuine stress incontinence after

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Abstract
Objective: To evaluate the medium‐term outcome of gluteraldehyde cross‐linked (GAX) collagen in the treatment of genuine stress incontinence in women.Patients and methods: The study comprised 111 women (age range 33–90 years) with genuine stress incontinence who were treated with para‐urethral collagen injections between 1990 and 1995. The patients were followed prospectively and their clinical outcome documented. Pre‐ and post‐operative urodynamic data were examined to determine any prognostic indicators.Results: The overall results at a minimum 2‐year follow‐up (mean 3.3) showed 25% of patients to be dry and a further 40% improved. Although there were significant changes in some urodynamic values, no predictive factors of success were identified. Previous surgery for stress incontinence did not influence the final outcome.Conclusion: Para‐urethral collagen injection is a safe and relatively simple procedure with acceptable results at the medium‐term follow‐up. It could be offered as a primary or secondary procedure to women with genuine stress incontinence who are unable or unwilling to undergo surgical treatment. Objective urodynamic assessment revealed no factors of prognostic significance.

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