Comparative penetration of azlocillin and mezlocillin into cerebrospinal fluid of normal rabbits and rabbits with experimentally induced Pseudomonas aeruginosa meningitis
Open Access
- 1 November 1982
- journal article
- research article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 22 (5) , 909-911
- https://doi.org/10.1128/aac.22.5.909
Abstract
The impacts of meningeal infection with Pseudomonas aeruginosa and route of drug administration on the penetration of azlocillin and mezlocillin into the cerebrospinal fluid of rabbits were evaluated. The penetration of both agents was increased to a similar degree in rabbits with meningitis compared with normal rabbits. The increase in penetration was greater after intravenous administration than after intramuscular administration.Keywords
This publication has 2 references indexed in Scilit:
- Azlocillin and Mezlocillin: New Ureido PenicillinsAntimicrobial Agents and Chemotherapy, 1978
- Activity of Azlocillin and Mezlocillin Against Gram-Negative Organisms: Comparison with Other PenicillinsAntimicrobial Agents and Chemotherapy, 1978