In vitro susceptibility of cephalothin-resistant Enterobacteriaceae to cefoxitin and BL-S786.
- 1 January 1977
- journal article
- research article
- Published by Japan Antibiotics Research Association in The Journal of Antibiotics
- Vol. 30 (4) , 326-329
- https://doi.org/10.7164/antibiotics.30.326
Abstract
The in vitro antibacterial activity of 2 agents relatively resistant to .beta.-lactamases, BL-S786 [7-[.alpha.-(2-aminomethylphenyl)acetamido]-3-[carboxymethyltetrazol-5-5 ylthio) methyl]-3-cephem-4-carboxylic acid) and cefoxitin, was tested against 123 recent different clinical isolates of cephalothin-resistant Enterobacteriaceae. BL-S786 showed considerable activity against Escherichia coli and lesser activity against Klebsiella pneumoniae with, respectively, 68% and 41% inhibited at 32 .mu.g/ml. Cefoxitin showed more activity in vitro against E. coli, K. pneumoniae, Serratia marcescens and Providencia stuartii. Cefoxitin appears to be a more promising agent for treating infections caused by cephalothin-resistant Enterobacteriaceae.This publication has 1 reference indexed in Scilit: