SIMULTANEOUS MEASUREMENT OF PLASMA-LEVELS OF D-PROPOXYPHENE AND Z-PROPOXYPHENE USING STABLE ISOTOPE LABELS AND MASS FRAGMENTOGRAPHY

  • 1 January 1976
    • journal article
    • research article
    • Vol. 14  (4) , 631-641
Abstract
When recemic propoxyphene was administered orally to dogs, plasma levels of d-propoxyphene were higher than those of l-propoxyphene. The half-life of d-propoxyphene was longer than that of the l-isomer. Measurements were performed by labeling 1 isomer with deuterium and then measuring d- vs. l- ratios by mass fragmentography. An i.v. experiment confirmed the preferential uptake of the l-isomer. The labeling position was sufficiently far removed from the point of metabolic attack in the molecule so that no interfering isotope effect existed.

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