Communication: Physiologic Surfactants Affecting Permeation and Bsl Lowering in Rabbit from Glibenclamlde Tablets

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Abstract
The physiologic surfactants (e.g. sodium taurocholate and sodium tauroglycocholate) were included in the tablet formulations to incrase the solubility, permeability and absorption of gliben-clamide. Sodium tauroglycocholate was found to increase the permeation, AUC, Cmaxl and %Frel with its increasing concentrations in tablets. Sodium taurocholate, at submicellar level, had incerased the permeation, AUC, Cmaxl and %Frel and decreased the above parameters beyond critical micelle concentration.