Gastric antisecretory agents. 2. Antisecretory activity of 9-[(aminoalkyl)thio]-9H-xanthenes and 5-[(aminoalkyl)thio]-5H-[1]benzopyrano[2,3-b]pyridines

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Abstract
A series of 9-[(aminoalkyl)thio]-9H-xathenes and 5-[(aminoalkyl)thio]-5H-[1]benzopyrano[2,3-b]pyridines possessing gastric antisecretory activity in the rat and dog is described. Many of the compounds possessed good activity in the pylorus-ligated rat and several inhibited histamine-stimulated gastric acid secretion in the dog. The mechanism of acid secretion inhibition is not related to anticholinergic or histamine (H2) receptor antagonism.