The Continuous Culture of Bacteria; a Theoretical and Experimental Study

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Abstract
A theoretical treatment of continuous culture is given, which allows quantitative predication of the steadystate concentrations of bacteria and substrate in the culture, and how these may be expected to vary with change of medium, concentration and flow-rate. The layout and operation of a small pilot plant for the continuous culture of bacteria are described. Results are given of a series of experiments on the continuous culture of Aerobacter cloacae in a chemically defined medium. It is concluded that continuous culture may usually be expected to show a 5 to 10-fold increase in output as compared with a batch process.

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