BIOPHARMACOLOGICAL INVESTIGATION OF 6,6'METHYLENE-BIS-2,2,4-TRIMETHYL-1,2-DIHYDROQUINOLINE (MTDQ) A RADICAL BINDING ANTIOXIDANT OF SECONDARY AMINE TYPE

  • 1 January 1977
    • journal article
    • research article
    • Vol. 24  (3) , 253-258
Abstract
The evidence of free radicals in [rat] tumor tissue and the possibility of their experimental influence by antioxidants justifies the search for new pharmacological groups of tumor inhibiting agents. A sterically inhibited, heterocyclic, bifunctional, nontoxic radical binding antioxidant of secondary amine type was synthesized. The structural change is interpreted with the possibility of recombination characteristic for secondary amine groups and the double chain closing effect. The conjugation effect secures mobility of the H atom. The compound contains 10-12% dimer-trimer of higher biological activity than monomers, due to higher molecular weight. An additional pharmacodynamic advantage compared to hitherto known antioxidants consists in its lower vapor volatility and biradicality.

This publication has 0 references indexed in Scilit: