The First Synthesis of the Bis(indole) Marine Alkaloid Caulersin
- 1 October 1999
- journal article
- letter
- Published by Georg Thieme Verlag KG in Synlett
- Vol. 1999 (10) , 1651-1653
- https://doi.org/10.1055/s-1999-2903
Abstract
The first synthesis (seven steps) of the bis(indole) marine alkaloid caulersin is described. Construction of the central seven-membered ring is based on a Michael-type addition of the appropriate 2,3′-bis(indolyl)ketone to methylvinylketone followed by intramolecular nucleophilic substitution of the resulting 3-oxoalkylated product.Keywords
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