Comprehensive transcriptional profiling of prion infection in mouse models reveals networks of responsive genes
Open Access
- 3 March 2008
- journal article
- Published by Springer Nature in BMC Genomics
- Vol. 9 (1) , 114
- https://doi.org/10.1186/1471-2164-9-114
Abstract
Prion infection results in progressive neurodegeneration of the central nervous system invariably resulting in death. The pathological effects of prion diseases in the brain are morphologically well defined, such as gliosis, vacuolation, and the accumulation of disease-specific protease-resistant prion protein (PrPSc). However, the underlying molecular events that lead to the death of neurons are poorly characterised.Keywords
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