Abstract
In this series of experiments it was shown that a round window seal produced with a muscle autograft or a Teflon felt disc glued to the electrode, prevented a Staphylococcus aureus infection in the bulla extending to the cochlea. The seal following a fascial autograft also prevented β-haemolytic streptococci type A spreading to the basal turn of the cochlea. On the other hand, Dacron™ velour is contra-indicated as it was associated with a strong inflammatory response and a high incidence of infection. The studies also indicated that infection can extend to the cochlea before the round window membrane has healed. The junctional area between the graft and the margin of the round window niche, is a potentially vulnerable site.