Direct Catalytic Asymmetric Aldol-Type Reaction of Aldehydes with Ethyl Diazoacetate
- 29 March 2003
- journal article
- Published by American Chemical Society (ACS) in Organic Letters
- Vol. 5 (9) , 1527-1530
- https://doi.org/10.1021/ol0343257
Abstract
The direct aldol-type condensation of aldehydes with ethyl diazoacetate catalyzed by the chiral complex of BINOL derivatives-Zr(O(t)Bu)(4) gave beta-hydroxy alpha-diazo carbonyl compounds with moderate enantioselectivities (53-87% ee). [reaction: see text]Keywords
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