Preparation of S,S'-Dibenzyloxytocin and Its Reconversion to Oxytocin.*
- 1 December 1953
- journal article
- research article
- Published by Frontiers Media SA in Experimental Biology and Medicine
- Vol. 84 (3) , 723-725
- https://doi.org/10.3181/00379727-84-20765
Abstract
The benzylation of oxytocin by reduction with metallic Na in liquid ammonia and subsequent treatment with benzyl chloride results in the formation of an S,S[image]-dibenzyl derivative which is biologically inactive. The activity is regenerated by reduction of benzylated oxytocin with Na in liquid ammonia and a comparison of the material, after oxidation, with oxytocin itself led to the conclusion that the biologically active material so formed represents oxytocin.Keywords
This publication has 7 references indexed in Scilit:
- ELECTROPHORETIC PROPERTIES OF OXYTOCINJournal of Biological Chemistry, 1953
- Further Distribution Studies on the Oxytocic Hormone of the Posterior Lobe of the Pituitary Gland and the Preparation of an Active Crystalline FlavianateJournal of Biological Chemistry, 1952
- THE DESULFURIZATION OF OXYTOCINJournal of Biological Chemistry, 1951
- THE OXIDATION OF OXYTOCIN WITH PERFORMIC ACIDJournal of Biological Chemistry, 1951
- STUDIES ON HIGH POTENCY OXYTOCIC MATERIAL FROM BEEF POSTERIOR PITUITARY LOBESJournal of Biological Chemistry, 1950
- CHROMATOGRAPHY OF AMINO ACIDS ON STARCH COLUMNS. SOLVENT MIXTURES FOR THE FRACTIONATION OF PROTEIN HYDROLYSATESJournal of Biological Chemistry, 1949
- CHROMATOGRAPHY OF AMINO ACIDS ON STARCH COLUMNS. SEPARATION OF PHENYLALANINE, LEUCINE, ISOLEUCINE, METHIONINE, TYROSINE, AND VALINEJournal of Biological Chemistry, 1948