Results of surgical treatment of stage IIIA non-small cell lung cancer

Publisher Website
Google Scholar
Abstract
From 1975 to 1993, 665 patients with non-small cell lung carcinoma(NSCLC) were studied in our Unit. Of the 55 stage IIIA patients submittedto resection, 50 were followed-up in order to evaluate the effectiveness ofsurgery and to identify which variables had a prognostic impact onsurvival. The expectancy of survival at 3,5 and 10 years was 31.7, 19.5 and13.7%, respectively. When the analysis was limited to N2 patients, 3,5- and10-year survival rates were 20.9, 14 and 7%, respectively. Regarding the"TN" factor, the T3N0 subset presented the highest expected survival (24.8and 18.6% at 5 and 10 years). With regard to the "T3" factor and type ofsurgery, peripheral tumors submitted to en bloc resection of the chest wallshowed the best 5-year survival rate (42.9%), whereas extrapleuralresections--even for tumors confined to the parietal pleura--showed a5-year survival rate of 14.3%. A slightly higher risk of death was observedin tumors originating in the superior sulcus (SST). No patients withmediastinal pleura and pericardium involvement survived more than 34months. With univariate analysis, "N2" was the variable most significantlyassociated with a negative prognosis when related to T3 (T3N2 vs T3N0 0.025< P < 0.05) or non-epidermoid tumor (no survivors at 3 years; N2epidermoid vs N2 non-epidermoid tumor P < 0.05). Applying multivariateanalysis, epidermoid cell type, even if exclusively for N2 tumors, was anindependent prognostic factor, showing a favorable impact on survivalexpectancy (27.8% at 90 months).

This publication has 0 references indexed in Scilit: