Silver Ion as Modifier for High Performance Liquid Chromatography of Menaquinones

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Abstract
The chromatography of the homologous series of menaquinones with 0 to 10 isoprenoid units on reverse phase high performance liquid chromatography is investigated with octyldecylsilica and C-8 silica supports. Addition of chloroform decreases retention (k'') of all menaquinones and vitamin K1 linearly with respect to log k''. The addition of Ag ion decreases k'' of menaquinones with 3 or more isoprenoid units with a non-linear relationship to log k''. There is a linear relationship at a given Ag ion concentration between log k'' and the number of isoprenoid units. There is no effect of Ag ion on vitamin K1, although there is 1 double bond in the side chain.

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