Meningococcal Meningitis — Suboptimal Response to Cephalothin Therapy
- 22 May 1969
- journal article
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 280 (21) , 1163-1165
- https://doi.org/10.1056/nejm196905222802107
Abstract
Meningococcal disease continues to be a serious problem, and increasing recognition of sulfadiazine-resistant strains1 2 3 4 renders sulfonamide therapy untenable. For most persons either penicillin G or ampicillin has supplanted sulfonamides as the antimicrobial agents of choice in the treatment of meningococcal disease in man.3 , 5 However, selecting therapy for penicillin-sensitive patients remains a problem. Various cephalosporin derivatives have been suggested as bactericidal alternatives in life-threatening infections, but little experience with these agents has been reported in association with meningococcal disease. Binns and Pankey6 described a patient with meningococcal meningitis treated with cephalothin whose response was equivocal. They expressed the hope that others . . .Keywords
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