Early Growth of Rabbit Trophoblast

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Abstract
The growth of rabbit trophoblast during the period preceeding placenta formation was studied by calculations made from measurements of blastocysts removed from the mother at known stages in development. Growth rates, as determined from doubling time and mitotic duration of trophoblast surface cells, stay constant up to 6 days post coitum but begin to change thereafter. Production of syncytiotrophoblast, cell death, and lengthening of mitotic duration are considered as factors contributing to the reduction in growth. The mitotic index does not change significantly throughout the period studied, averaging 4.42%. Fluid accumulates in the blastocyst at a constant accelerating rate when expressed as volume/trophoblast cell/hour/hour. The existence of some type of transtrophoblast pump is inferred to account for the rapid rate observed. Correlations between trophoblast cell size, onset of fluid accumulation and blastulation are noted.

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