POLIOMYELITIS - IMMUNOGLOBULIN-CONTAINING CELLS IN THE CENTRAL NERVOUS-SYSTEM IN ACUTE AND CONVALESCENT PHASES OF THE HUMAN-DISEASE

  • 1 January 1980
    • journal article
    • research article
    • Vol. 40  (1) , 42-48
Abstract
The immunoperoxidase method was used to demonstrate the presence of immunoglobulin[Ig]-containing cells in the CNS in acute and convalescent phases of poliomyelitis. These cells were found in considerable numbers in areas of damage during the acute phase and persisted at the same sites, although in smaller numbers, during the convalescent phase for at least 8 mo. Most positively stained cells were plasma cells. IgA was the commonest H chain type demonstrated, with lesser amounts also of IgG and, during the acute phase, IgM. In the acute phase more .lambda. than .kappa. L chain was demonstrated but in the convalescent phase this ratio was reversed. More L chain than H chain was demonstrable during the acute phase. The significance of these results is briefly discussed.